tag:blogger.com,1999:blog-4082643038671225434.post1555050089009676840..comments2023-10-07T01:34:01.774-07:00Comments on Case of the Day: People Like That Are The Only People HereCraighttp://www.blogger.com/profile/17072102331564743101noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-4082643038671225434.post-54877481224844839382008-02-29T10:29:00.000-08:002008-02-29T10:29:00.000-08:00People Like That Are The Only People HereThis is W...People Like That Are The Only People Here<BR/><BR/>This is Wilms’ tumor, the most common childhood renal malignancy and the fourth most common childhood cancer. It is associated with several congenital syndromes, WAGR (aniridia, GU abnormalities, mental retardation, Wilms’ tumor) and Denys-Drash syndrome (renal disease, male pseudohermaphroditism, Wilms’ tumor), and Beckwith-Wiedemann syndrome (increased childhood tumors). The genes involved are WT1 and WT2. Pathogenesis involves abnormal renal development with metanephric blastema formation without tubular or glomerular differentiation. Most are solitary, but bilateral involvement is possible. Histologically, the tumor has blastemal undifferentiated cells, stromal cells, and epithelial cells.<BR/><BR/>Sources: UpToDate; pathology.washington.eduCraighttps://www.blogger.com/profile/17072102331564743101noreply@blogger.comtag:blogger.com,1999:blog-4082643038671225434.post-30411646369575880652008-02-28T16:11:00.000-08:002008-02-28T16:11:00.000-08:00wilm's tumor?wilm's tumor?Alexhttps://www.blogger.com/profile/06972701448751949861noreply@blogger.com