tag:blogger.com,1999:blog-4082643038671225434.post2989103792525587193..comments2023-10-07T01:34:01.774-07:00Comments on Case of the Day: Basic ImmunologyCraighttp://www.blogger.com/profile/17072102331564743101noreply@blogger.comBlogger1125tag:blogger.com,1999:blog-4082643038671225434.post-87530908339818706062007-10-10T07:52:00.000-07:002007-10-10T07:52:00.000-07:00Basic ImmunologyThe mutation in the common gamma c...Basic Immunology<BR/><BR/>The mutation in the common gamma chain is found in X-linked SCID, which also explains why boys are more affected than girls. This gamma c chain is required for functional IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 receptors. A deficiency leads to severe combined immunodeficiency, a loss of both arms of the adaptive immune system. It is severe and can lead to recurrent infections.<BR/><BR/>One unusual and fascinating clinical presentation of SCID is graft versus host disease due to maternal chimerism. Maternal T lymphocytes are engrafted into the neonate transplacentally during the perinatal period. The neonate lacks alloreactive T lymphocytes to eliminate the maternal T cells (the neonate of course has inherited only half of the maternal genes). The maternal T cells then mount a graft versus host disease on the neonate.<BR/><BR/>Source: Alex Penn, Somatic Gene Therapy by Patricia Chang through Google Books, Wikipedia.Craighttps://www.blogger.com/profile/17072102331564743101noreply@blogger.com