tag:blogger.com,1999:blog-4082643038671225434.post3715317490487377236..comments2023-10-07T01:34:01.774-07:00Comments on Case of the Day: History LessonCraighttp://www.blogger.com/profile/17072102331564743101noreply@blogger.comBlogger1125tag:blogger.com,1999:blog-4082643038671225434.post-10864782824021776862007-12-10T08:12:00.000-08:002007-12-10T08:12:00.000-08:00History LessonThe patient was exposed to the chemi...History Lesson<BR/><BR/>The patient was exposed to the chemical diethylstilbestrol (DES) in utero. So-called DES daughters (if the mother received DES during pregnancy) have a 40-fold increase in risk of clear cell adenocarcinoma of the vagina and cervix, usually diagnosed in the late teens and twenties (most cases in non-exposed women occur postmenopausally). These patients are also at higher risk for congenital anomalies and epithelial changes of the reproductive tract, fertility problems, earlier menopause, and breast cancer. DES is a nonsteroidal estrogen initially used for postmenopausal symptoms and prevention of pregnancy related problems (such as miscarriage). Its use was stopped in 1971 after its adverse health effects were discovered. It is the only firmly established transplacental carcinogen in humans.<BR/><BR/>Source: UpToDate.Craighttps://www.blogger.com/profile/17072102331564743101noreply@blogger.com