A child presents with mucocutaneous bleeding but his platelet counts are normal. On a non-anticoagulated peripheral blood smear, you see single isolated platelets without platelet clumping. There is no response when you stimulate the platelets with ADP, epinephrine, or collagen. However, when you stimulate with ristocetin, you get a normal reaction.
Challenge: The child has developed antibodies against what complex? What is the disease called?
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I put together these medical challenges. The cases are hypothetical and do not necessarily represent actual or typical presentations of medical diseases. Disclaimer is at the bottom of this page.
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3 comments:
glanzzmann's or bernard-soulier's? can't remember which gp is which.
whhops, didn't read the part where it was an antibody-mediated disease... my two guesses are genetic deficiencies i think.
nice
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Platelet
This is Glanzmann thrombasthenia, a defect in platelet glycoprotein IIb/IIIa complex.
Source: UpToDate.
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