Thursday, January 2, 2014

Cheesesteak

This FISH analysis comes from a 50 year old radiology technician who presented to his primary care physician with fatigue, weight loss, and abdominal pain. He has splenomegaly on exam but no lymphadenopathy. Laboratory tests show a remarkable leukocytosis with myelocytes and segmented neutrophils. There is also an absolute basophilia and absolute eosinophilia. He also has thrombocytosis and a normochromic, normocytic anemia.

Challenge: What's your diagnosis?

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3 comments:

Anonymous said...

CML, FISH shows rearrangement of BCR-ABL

January 9, 2014 at 10:12 PM
webhill said...

is that the Philadelphia chromosome? He has leukemia. And I only know about the Philadelphia chromosome because I read about when I was a kid about a girl with leukemia and they mentioned that chromosome - they didn't bring this up in vet school at any time :). I wish I could remember the name of the book, it's driving me nuts now!

January 16, 2014 at 12:43 PM
Craig said...

you're right! good memory - i wonder what that book is
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Cheesesteak

This is chronic myeloid leukemia, a myeloproliferative disorder associated with the BCR-ABL t(9;22) fusion gene, also known as the Philadelphia chromosome.

Sources: UpToDate; Wikipedia.

January 20, 2014 at 9:50 AM

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