Wednesday, April 30, 2008


A 52 year old male presents with splenomegaly, fatigue, weakness, weight loss, pancytopenia, and a smear shown above.

Challenge: What is the diagnosis and what stain is shown in the image above?

Image shown under fair use.


tree said...

I think Rogaine is the last thing his B cells need :(

Hairy cell leukemia, TRAP stain

Alex said...

it's a TRAP!

Craig said...

haha good job!

This is hairy cell leukemia (minoxidil or Rogaine is used to promote hair regrowth). Hairy cell leukemia is a chronic B cell lymphoproliferative disorder; the cells have prominent irregular cytoplasmic projections. This is a stain for tartrate-resistant acid phosphatase (TRAP), characteristic of hairy cell leukemia.

Sources: UpToDate;