Monday, July 7, 2008


This is a kidney biopsy from an African American patient with acute onset peripheral edema, low albumin, severe proteinuria, hypertension, and microscopic hematuria. The cause is idiopathic. On the biopsy, some other glomeruli look completely normal.

Challenge: What's the diagnosis?

Image shown under fair use.


Alex said...

focal segmental

tree said...

I had a patient with this today!

Focal segmental glomerulosclerosis

Craig said...


This is focal segmental glomerulosclerosis (FSGS) which for unknown reasons is seen more commonly in African Americans. There are also inherited forms of FSGS and secondary causes of FSGS.

Sources: UpToDate;