Monday, December 1, 2008


A child presents with mucocutaneous bleeding but his platelet counts are normal. On a non-anticoagulated peripheral blood smear, you see single isolated platelets without platelet clumping. There is no response when you stimulate the platelets with ADP, epinephrine, or collagen. However, when you stimulate with ristocetin, you get a normal reaction.

Challenge: The child has developed antibodies against what complex? What is the disease called?


Alex said...

glanzzmann's or bernard-soulier's? can't remember which gp is which.

Alex said...

whhops, didn't read the part where it was an antibody-mediated disease... my two guesses are genetic deficiencies i think.

Craig Chen said...


This is Glanzmann thrombasthenia, a defect in platelet glycoprotein IIb/IIIa complex.

Source: UpToDate.