An older Caucasian patient with a cardiac arrhythmia treated with the medication shown above presents with fever, myalgias, arthralgias, and pleuritis. Laboratory testing shows that the patient has antihistone antibodies and is ANA positive.Challenge: What's the drug, and what's the disease?
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procainamide, drug-induced lupus erythematosus
procainamide?
go chemistry!
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Wolf
Lupus means wolf in Latin. This is drug-induced lupus by procainamide. Other drugs that can cause lupus include hydralazine, minocycline, diltiazem, penicillamine, isoniazid, quinidine, anti-TNF, interferon-alfa, methyldopa, chlorpromazine, and practolol.
Sources: UpToDate; Wikipedia.
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