Thursday, December 15, 2011


A 42 year old woman undergoes screening colonoscopy because she has a positive family history for cancer. The patient's mother died of endometrial cancer; her sister has colon cancer at age 39; her grandmother (on her mother's side) had ovarian cancer and colon cancer; her uncle (on her mother's side) had transitional cell cancer of the ureter. Her colonoscopy is shown above.

Challenge: What do you suspect?

Image is shown under GNU Free Documentation License.


jbwpac said...


Craig Chen said...

You're right, though I was specifically looking for Lynch syndrome which greatly increases the risk of such cancers.

This is Lynch syndrome, or hereditary nonpolyposis colorectal cancer (HNPCC). There is a greatly increased risk of colorectal cancer, endometrial cancer, and other cancers in this autosomal dominant disease in DNA mismatch repair genes.

Sources: UpToDate; Wikipedia.