In my leisurely late night reading, I came across a 2007 article in the Journal of Medical Biography describing this 16th century celebrity and an eponymous sign named after her. Apparently, people with "abbreviated eyebrows" as shown in this portrait may have a certain disease. The sign was misnamed as this queen did not have the disease, but if she did, she might complain of the following symptoms: fatigue, slow movement, slow speech, constipation, and weight gain. Her exam might reveal delayed deep tendon reflexes, bradycardia, dry skin, and coarse hair.
Challenge: What disease am I talking about?
Image is in the public domain.