A 25 year old Caucasian woman (G1P0) with epilepsy presents to prenatal diagnosis clinic because a routine maternal serum AFP screen at 16 weeks showed a value 2.5 multiples of the median. An ultrasound confirms the diagnosis.
This CT is from a woman who has had two C-sections in the past now presenting with abdominal distension, vomiting, and crampy periumbilical pain every five minutes. She says she hasn't passed flatus in a while.
You decide to do an international rotation in Africa where you see a malnourished patient in clinic with poor bone growth, non-specific skin findings, a mildly immunocompromised state, and the eye finding above. He says he has poor vision at night.
This female infant was born at home at 36 weeks gestation to a 40 year old mother. Parents declined routine newborn screening. Like the vast majority of infants with this disease, she did not have any clinical manifestations at birth because the defect is compensated by maternal placental transfer of the deficient molecule, shown below.
She's now six weeks old and still has jaundice. She also has a bit of lethargy, a hoarse cry, poor feeding, macroglossia, an umbilical hernia, large fontanels, and hypotonia.
In my leisurely late night reading, I came across a 2007 article in the Journal of Medical Biography describing this 16th century celebrity and an eponymous sign named after her. Apparently, people with "abbreviated eyebrows" as shown in this portrait may have a certain disease. The sign was misnamed as this queen did not have the disease, but if she did, she might complain of the following symptoms: fatigue, slow movement, slow speech, constipation, and weight gain. Her exam might reveal delayed deep tendon reflexes, bradycardia, dry skin, and coarse hair.
This child complained about gradual onset sore throat, malaise, and low grade fever. The gram stain is shown below.
Challenge: What is the organism?
A 35 year old G5P4 Asian woman with 3 prior C-sections at 34 weeks gestation presents with painless vaginal bleeding. She has no contractions, no pain, no loss of fluid, and fetal movement is present. 
I know this is a hard picture to see but we're looking at that nodular red-purple skin lesion in this gentleman. He presented to his primary care physician complaining of fever, chills, malaise, headache, anorexia, and weight loss. Concerned about these constitutional symptoms, the primary care doctor sent off a bunch of labs and found that the patient was HIV positive with CD4 count 95 cells/mm3. He was then referred to you for this odd skin lesion.
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