The patient's disease is a very aggressive non-Hodgkin's lymphoma, but with chemotherapy, you induce a remission. Unfortunately, a decade later, the patient dies. He had dyspnea on exertion, impaired exercise capacity, orthopnea, paroxysmal nocturnal dyspnea, and peripheral edema. Autopsy shows the following:
You attribute this unfortunate death to this:
Challenge: What is that chemical?First image shown under fair use, second image shown under GNU Free Documentation License.
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3 comments:
as a class, anthracyclines can cause CHF and cardiomyopathy. looked it up and daunorubacin has the same structure.
what do you mean by "b cell symptoms" - is there a general decision-making process for assessing NHLs?
Daunorubicin
nice job - think "B symptoms" is fever/chills/weight loss and you talk about it in relation to lymphomas
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Path
The treatment for aggressive non-Hodgkin’s lymphoma includes an anthracycline (such as daunorubicin, shown in this case). Anthracyclines can cause cardiotoxicity, leading to symptomatic heart failure from dilated cardiomyopathy even a decade after treatment.
Sources: UpToDate; Wikipedia; www.bmb.leeds.ac.uk.
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