Friday, March 7, 2008

Star Light, Star...

A six year old girl begins to develop breast buds and menstrual periods. You note ovarian cysts as well as these findings.

Challenge: What's the diagnosis?

First image is in the public domain, second image shown under fair use.

2 comments:

Alex said...

Madeline-Albright syndrome

Craig said...

Star Light, Star…

McCune-Albright syndrome is a rare disorder with the triad of sexual precocity, café-au-lait pigmentation (first image), and polyostotic fibrous dysplasia of bone (second image). The molecular mechanism is a mutation in an alpha subunit of a G protein. It only occurs in girls.

Sources: UpToDate history.nih.gov; brighamrad.harvard.edu.