A six year old girl begins to develop breast buds and menstrual periods. You note ovarian cysts as well as these findings.
Challenge: What's the diagnosis?
First image is in the public domain, second image shown under fair use.
Friday, March 7, 2008
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Madeline-Albright syndrome
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McCune-Albright syndrome is a rare disorder with the triad of sexual precocity, café-au-lait pigmentation (first image), and polyostotic fibrous dysplasia of bone (second image). The molecular mechanism is a mutation in an alpha subunit of a G protein. It only occurs in girls.
Sources: UpToDate history.nih.gov; brighamrad.harvard.edu.
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