An 18 year old man gets into a car accident and requires blood transfusion. When he gets transfused with the first unit, he experiences anaphylaxis. He has never had a blood transfusion in the past, but testing shows IgG antibodies against IgA. The only other thing he notes is that as a child, he had recurrent upper and lower respiratory tract infections with bacteria like S. pneumoniae and H. influenza.
Challenge: What's the diagnosis here?
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I put together these medical challenges. The cases are hypothetical and do not necessarily represent actual or typical presentations of medical diseases. Disclaimer is at the bottom of this page.
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3 comments:
cross reaction of antibodies, h/o IgA nephropathy?
selective IgA def
Yes, IgA is involved, its a deficiency.
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Allergic
This is IgA deficiency which can present with recurrent sinopulmonary infections, autoreactive antibodies and diseases, gastrointestinal abnormalities, and anaphylactic reactions to blood products.
Source: UpToDate.
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