Monday, May 12, 2008


A 30 year old G1P1 who gave birth to a healthy baby boy two days ago presents with lethargy, anorexia, weight loss, and inability to lactate. The course of pregnancy was prolonged, and multiple units of blood were given. If the tissue in question were to be examined histologically, this would be seen:

Challenge: What's the diagnosis?

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Alex said...

sheehan's syndrome?

mika said...

Don't scare me like this! I think it's Sheehan syndrome/postpartum hypopituitarism

Craig said...


This is Sheehan syndrome, pituitary infarction after postpartum hemorrhage which can lead to hypopituitarism. This may be due to massive growth of the pituitary during pregnancy, leading to susceptibility to ischemia. The histology shows “ghost architecture and acellular area of infarction.”

Sources: UpToDate;